Secondary amyloidosis: diagnosis from an endometrial biopsy

Noninvasive diagnosis of biopsy-proven cardiac amyloidosis.

OBJECTIVES This study analyzed the utility of electrocardiographic (ECG) and echocardiographic findings in the diagnosis of amyloidosis proven by endomyocardial biopsy. BACKGROUND Cardiac amyloidosis is associated with characteristic ECG and echocardiographic changes, yet each finding alone is relatively nonspecific. A combination of noninvasive prognostic parameters would be desirable for th...

Endometrial Biopsy for Diagnosis. An Analysis of 1,217 Samples

The diagnostic value of endometrial biopsy in many gynsecologieal conditions particularly in the investigation of causes for sterility in women, menstrual disturbances, endometrial response to various hormones, infections and malignant disease is being recognized and the histological appearances accepted as more dependable now than was the case in the past. Along with other morbid histology mat...

Diagnosis of secondary amyloidosis in alkaptonuria

BACKGROUND Alkaptonuria (AKU) is an inborn error of catabolism due to a deficient activity of homogentisate 1,2-dioxygenase. Patients suffer from a severe arthropathy, cardiovascular and kidney disease but other organs are affected, too. We found secondary amyloidosis as a life-threatening complication in AKU, thus opening new perspectives for its treatment. We proved that methotrexate and anti...

Biopsy of subcutaneus fatty tissue for diagnosis of systemic amyloidosis.

BACKGROUND The diagnosis of systemic amyloidosis is determined through histological material from biopsy of different parenchymal organs, which have high diagnostic and informative value, but hide a high risk of bleeding because of the accumulation of amyloid in the vessels' wall. The main methods are kidney, liver, gastro-intestinal tract biopsy and aspiration of subcutaneous fatty tissue. The...

Case Report: Diagnosis of Dual-Biopsy Negative Severe Cardiac Amyloidosis